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Endocr Connect 2023;12:e220504.ArticlePubMedPMC 4

Heroin, an opioid, primarily modulates G protein-coupled receptor activity and affects neuronal excitability and reward pathways

Schedule: Daily subcutaneous injections for 20 consecutive days, followed by 46 months off-cycle

Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willett WC, and Rozen R (1996)

Compared with older pharmacologic options, GLP-1 receptor agonists and newer incretin-based therapies generally offer greater average weight reduction, but they also raise specific issues related to gastrointestinal tolerability, long-term continuation, affordability, and access ( 6 Safety and practical prescribing considerations in KOA patients Safety considerations are particularly important when GLP-1 receptor agonists are considered for patients with obesity-related KOA, because this population often includes older adults, patients with multimorbidity, and individuals approaching elective arthroplasty