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As one obesity medicine specialist explained, "the increased risk of thyroid cancers is specifically in those with a personal or family history of multiple endocrine neoplasia 2 (MEN2) syndrome or medullary thyroid carcinoma [MTC]." Reassuringly, randomized trials failed to detect any increase in calcitonin levels and did not confirm the risk of pancreatitis, whereas a significant increase in cholelithiasis was highlighted
This is one reason combination formulations have become popular in endocrinology research over the past decade
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