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Weight and anthropometric outcomes Percentage weight loss The average percentage weight-loss trajectories with semaglutide and placebo over 4 years of observation are shown in Fig
For others it can take a few weeks longer depending on lifestyle habits
Physician-supervised drips formulated for what your body actually needs
In the first head-to-head trial, SURMOUNT-5 (2025), tirzepatide beat semaglutide directly 20.2% versus 13.7% over 72 weeks (New England Journal of Medicine, 2025)
But its not nearly as effective for weight loss as the shot: In studies, diabetic patients on the highest dose of Rybelsus lost just 8 pounds
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