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Q: What are the possible side effects
Potential Benefits: Significant Weight Loss: When combined with GLP-1 therapy, Cagrilintide has led to greater reductions in body weight than GLP-1s alone in clinical trials
Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136
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E., Briss, P
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