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Studies and clinical trials have shown that these medications can help sustain weight loss over the long term when used as part of a comprehensive treatment plan that includes diet and exercise
There is no one size fits all plan
Anal Chem 65 : 367373
The human studies that do exist are typically small (often fewer than 100 participants), short in duration (commonly eight to twelve weeks), and methodologically inconsistent, with significant heterogeneity in dosing, formulation, and outcome measures
Its quite tolerable, and most report it as virtually painless
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