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Alex Saucedo is a Dual Board-Certified Physician and dynamic healthcare leader with over eight years of experience bridging clinical excellence and modern, scalable healthcare delivery

In fact, SGLT2-i induced osmotic diuresis and reduction in plasma volume potentially activate systemic RAAS, leading to an initial increase of renin levels in the first three-six months of treatment (53)

Additionally, Semaglutide reduces oxidative stress by decreasing the production of reactive oxygen species (ROS) and increasing the activity of antioxidant enzymes

The peptide normalized lower esophageal sphincter pressure in rat models of GERD, suggesting potential for addressing underlying pathophysiology rather than merely symptom suppression

Some effects like improved sleep may be noticed within the first week