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As in prior experiments with GEP44, no indicators of nausea or malaise (e.g., changes in responsiveness, behavior, coat appearance, or facial expressions such as orbital tightening and nose/cheek flattening) were observed with GEP12 dosing

The results also fire a shot across the bows of other therapies for HFpEF, including SGLT2 inhibitors from AstraZeneca and Eli Lilly/Boehringer Ingelheim respectively Farxiga (dapagliflozin) and Jardiance (empagliflozin) as well as Novartis' Entresto (sacubitril/valsartan)

Garcinia Cambogia may also help improve mood by increasing serotonin levels in the brain, which might help reduce emotional eating

To view or add a comment, sign in GLP-1 Receptor Agonists: Extending Their Reach to Peripheral Artery Disease JAMA | July 2026 The clinical benefits of GLP-1 receptor agonists continue to expand

10.1073/pnas.0712038105 104 LiX.WangN.YinB.FangD.JiangT.FangS.et al (2016)