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NF-kB activation drives the chronic spinal inflammation and new bone formation (syndesmophyte development) that characterizes AS progression
Its multi-receptor activity gives it a broader research profile than more selective melanocortin agonists
Those who received Wegovy lost roughly 35 lbs (15.9 kg) compared to the 6 lbs (2.7 kg) weight loss in the placebo group
Kalogeraki A, Kafousi M, Ieromonachou P, Giannikaki E, Vrekoussis T, Zoras O, et al
The overlapping GI side effect profiles mean some users experience slightly worse tolerability than with plain tirzepatide
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