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254 NAD + metabolism programs immunity and inflammation NAD + , along with citrate and succinate, is a novel class of metabolites with inflammatory signaling capacity, linking the NAD + metabolism to the programming of immune responses

Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

It leads to decreased inflammation and metabolic health improves

For cell treatment by APAP precursors, HepaRG cells and primary human hepatocytes were first incubated with 50 g/ml of APAP or APAP-cys in the maintenance medium described above, during 0.5 h, 2 h, 6 h, 24 h, or 48 h, to optimize the incubation time required to detect APAP metabolites