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The available pharmacokinetic literature is animal work in rats and dogs describing rapid plasma clearance
It occurs as the protective cartilage that cushions the ends of bones deteriorates over time
Therefore, the means of assessing barrier functions were different to the approaches by the electrophysiologists and consisted of measuring translocation of bacteria or bacterial products like endotoxin from the gut into the portal vein, the liver or the systemic bloodstream
Rubiolo JA, Mithieux G, Vega FV
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