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These data suggest that ghrelin may aid in two ways: (1) by amplifying the remaining dopaminergic signaling through the D1R-GHSR1a dimer, and (2) by providing neuroprotective effects that may aid in slowing the progression of further dopaminergic degeneration, which may be the result of GHSR signaling alone

Fowkes MM, Lalonde T, Yu L, Dhanvantari S, Kovacs MS, Luyt LG

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It has been speculated that oxidative stress as well as mitochondrial damage may act together in inducing neurodegeneration

Among them, the Ser-65 residue was generally conserved across all GST classes