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On the other hand, administration of tirzepatide at a dose of 70 nmol/kg/day, resulted in a significant weight loss associated with shorter femur compared to saline-treated diabetic mice, but no evident alterations of bone microarchitecture or strength [69]

65 The aa arginine promotes insulin secretion in an ATP-independent manner, as it increases potassium permeability resulting in depolarisation and subsequent insulin secretion

Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, et al

In line with results from the present study, once-weekly semaglutide was found to be cost-effective throughout all these comparisons, even with differences in country-specific parameters such as healthcare systems, costs, and mortality