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Intra- and inter-day accuracy and precision must meet regulatory criteria: accuracy within +/-15% of nominal concentration (within +/-20% at LLOQ) and CV must confirm endotoxin below 1.0 EU/mL for parenteral products
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This is the biochemical reality behind post-exertional malaise (PEM)the debilitating "crash" that occurs when patients exceed their broken energy envelope
According to 2024 multi-society guidelines, many patients can continue these medications perioperatively with individualized risk assessment
With proper oversight, adjustments can be made based on individual tolerability and efficacy, ensuring the administration plan is tailored to each person's unique needs and health status
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