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38, Issue 3, 2025, pp
CagriSema 2.4 mg / 2.4 mg demonstrated 22.7% mean weight reduction in adults with overweight or obesity in REDEFINE 1, published in NEJM
According to NICE guideline NG28 , GLP-1 receptor agonists like Ozempic may be considered for adults with type 2 diabetes who have specific criteria, including a BMI of 35 kg/m or higher (adjusted for ethnicity) and specific problems associated with high weight, or a BMI lower than 35 kg/m where insulin would have significant occupational implications or weight loss would benefit other significant obesity-related comorbidities
GLP-1R is chiefly sorted either towards lysosomal degradation or recycled back to the plasma membrane, with the balance between the two predictive of insulinotropic efficacy of biased agonists (Jones et al., 2018b)
[1] [2] Tirzepatide is not indicated for type 1 diabetes and should not be used in combination with other GLP-1 receptor agonists or DPP-4 inhibitors
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