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FGFR2c and KLB (the gene encoding -Klotho) are induced upon exposure to FGF21 or an FGF21 analog, consistent with enhanced sensitivity to FGF21s metabolic effects (101)

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When patients present with a high anion gap metabolic acidosis, clinicians should first exclude common, treatable causes (eg, lactic acidosis, co-ingested drug administration, and ketoacidosis)

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