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IGF-1 improves the body ability to build lean muscle tissue , metabolize stored fat , and accelerate tissue repair
However, the blood-brain barrier crossing time and receptor binding process cannot be bypassed
Indeed, a randomized controlled trial showed that the combination of EGb 761 with metformin is more effective than metformin alone in improving the outcomes of patients with uncontrolled T2DM ( The GBE therapeutic potential in managing CVDs has not been always clinically observed
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