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Both reactions can be catalysed by protein disulphide isomerase (PDI) and possibly other oxidoreductases that share common domains with PDI (for a recent review, see Ellgaard & Ruddock, 2005)
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10.3390/biomedicines13010018 24 De RosaS
Therefore, N-acetylcysteine (NAC) is an effective antidote for APAP poisoning because it provides extra cysteines for GSH synthesis in the liver
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