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A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast
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Like basal-like tumours, it is triple negative (ER-, PR-, HER2-) but differs in having low Ki67 expression and elevated markers associated with epithelial-mesenchymal transition, indicating a distinct biological behaviour (142, 143)
Combined with BPC-157 and TB-500's separate repair-pathway activity, the stack covers structural ECM endpoints alongside vascular and cytoskeletal mechanisms