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Based on this mechanism, normalizing excess glutamate levels by metabotropic glutamate group 2/3 receptor agonists has led to potential identification of the first non-monoaminergic target with comparable efficacy as conventional antipsychotic drugs for treating positive and negative symptoms of schizophrenia
doi: 10.1038/nature21370 120 JinH.XuM.ChenH.ZhangS.HanX.TangZ.et al
Rev Environ Contam Toxicol 227:153
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