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In this approach, serine, threonine, or tyrosine residues intended for phosphorylation are incorporated as their native hydroxyl-containing amino acids, either without side-chain protection or with orthogonal protecting groups that can be selectively removed immediately before the phosphorylation step

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2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit

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