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The findings of this study have important significance for damage mechanisms in disorders like as thalassemia and sickle cell anemia
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However, when ROS production exceeds the capacity of cellular antioxidant defenses to remove these toxic agents, oxidative stress occurs, as confirmed by elevated specific biomarkers of oxidative damage in cyst fluid, including lactose dehydrogenase, lipid peroxidation, and 8-hydroxy-2-deoxyguanosine (126)
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