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PubMed, Maraslis, Flora Troina, et al
FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the intracellular interaction between FOXO4 and p53 in senescent cells, triggering p53-mediated apoptosis selectively in senescent rather than healthy proliferating cells
[12] Damage to the liver is not due to the drug itself but to a toxic metabolite ( N -acetyl- p -benzoquinone imine (NAPQI)) produced by cytochrome P-450 enzymes in the liver
Marked clinical inhibition of a wheal and flare response occurs in infants, children as well as adults within 20 minutes of one oral dose and lasts for 24 h
PLoS ONE 7(3):e32597
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