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Johns Wort acts similarly to several antidepressants, but is less effective, says Chris Pagnani, MD, the founder and medical director of Rittenhouse Psychiatric Associates in Philadelphia

This framework helps clarify when each approach may be most relevant

Furthermore, GLP-1 RAs exhibit vasodilatory effects by promoting endothelial nitric oxide (NO) synthesis, enhancing endothelial function with a consequent reduction of vascular resistance and an improvement in cardiac afterload [45, 46]

Serious but rarer risks include pancreatitis, gallbladder disease, and increased heart rate

Journal of Clinical Medicine, 12 (3), 772