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10.1001/jamaneurol.2013.929 JAMA Neurol

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Astaxanthin: A marine drug that ameliorates cerebrovascular-damage-associated Alzheimers disease in a zebrafish model via the inhibition of matrix metalloprotease-13

As previously described (Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)

These approaches encompass systemic administration of lactate-enriched solutions to provide metabolic support, as well as interventions aimed at inhibiting lactate production or transport as well as promoting its depletion to disrupt metabolic symbiosis in tumors, highlighting the dual therapeutic potential of lactate (150,151)