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The enhancement of Nrf2 transcription with sulforaphane or melatonin could benefit patients with LONG COVID (Post-Acute Sequelae of SARS-CoV-2 or Post-COVID-Syndrome), a significant proportion (approximately 40%) of individuals with COVID-19 experiencing a variety of symptoms (loss of smell and/or taste, fatigue, cough, aching pain, brain fog, insomnia, shortness of breath, and tachycardia) after 12 weeks (Jarrott et al., 2022
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The concentration differences of metabolites in tumor cells and the tumor microenvironment can significantly affect the proliferation, migration, and drug resistance of tumor cells [1], as well as the immune response of immune cells in the microenvironment [11, 12]
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