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According to the FDA Prescribing Information, tirzepatide has a half-life of approximately five days, meaning it takes about five days for half the drug to be eliminated from your system
R et al., 2022
That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route
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