week 5 tirzepatide Weeks 1–4: 2 mg • Weeks 5–8: 4 mg • Weeks 9–12: 6 mg Week 5 on tirzepatide and

However, some hormonal benefits, like reduced free testosterone levels, may persist

6 8 Second, the clinical consequences of the metabolic core are serious and long-term: impaired glucose tolerance, markedly elevated risk of type 2 diabetes, atherogenic dyslipidemia, MASLD, and cardiovascular risk factors cluster in PCOS

Signs of severe dehydration (dark urine, sunken eyes, and rapid heartbeat) Hypoglycemia (low blood sugar levels) occurs when retatrutide is used with other glucose-lowering medications

Your body becomes more efficient at using energy, which can result in fewer calories burned at rest

At the same time, insulin resistance weakens the bone-building signal, creating the diabetic bone paradox, where bones appear dense but fracture more easily.The lecture then explores bone-derived hormones, especially osteocalcin and lipocalin-2