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Published in Pharmaceuticals (PMID: 38675421), this 41-page open-access review proposes that BPC-157, while not meeting classical neurotransmitter criteria, functions as a cytoprotection mediator with neurotransmitter-like activity through a network of interconnected evidence. What Makes BPC-157 Unique BPC-157 is a 15-amino acid peptide (sequence: GEPPPGKPADDAGLV, molecular weight 1419) native and stable in human gastric juice for over 24 hours, showing no sequence homology with known gut peptides
Peer-reviewed RCT data in human tendon injury populations has not yet been published at scale
The safety profile is comparable to other established GLP-1 therapies, with the added benefit of once-weekly dosing improving patient compliance
B12 is essential for DNA synthesis the process that allows cells to replicate
BPC-157 appears to have inherited and amplified this cytoprotective function, which accounts for its well-documented effects on gut injury models
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