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The intrinsic pathway of apoptosis is activated by stimuli that lead to the permeabilization of the OMM and the subsequent release of proteins from the mitochondrial IMS, such as cytochrome c (Martinou and Green, 2001
Mitochondria and Glutathione The other component is that poorly functioning mitochondria lead to a more free radical generation that leads to more inflammation
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PLoS ONE 13:e0192682
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