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The clinical guide below reviews its mechanism, applications, safety profile, and combination strategies
General pathological changes, such as impaired blood supply and biomechanical alterations, are key contributors to the disease process
The advent of two new classes of glucose-lowering drugs (GLDs), the sodium-glucose cotransporter-2 inhibitors (SGLT2is) and the glucagon-like peptide-1 receptor agonists (GLP-1RAs), has led to a paradigm shift in type 2 diabetes treatment [3] since these drugs may reduce CVD risk and mortality effectively [4,5,6]
Proteoglycan synthesis requires adequate amino acids (from protein intake or collagen peptides), adequate cellular energy (glucose metabolism), and growth factor signaling (IGF-1, TGF-)
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