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Patients may experience this as generalized weakness, reduced exercise tolerance, or muscle discomfort, particularly during physical activity
The GLP-1R arm drives the central appetite suppression, delayed gastric emptying, and glucose-dependent insulin secretion familiar from semaglutide and tirzepatide 24
As discussed, there is considerable uncertainty about the absolute benefits of GLP-1 RA and SGLT2i for CVD outcomes in those with risk factors only
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