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Patients were randomized in a 3:1:1 ratio to receive either WEGOVY 7.2 mg, WEGOVY 2.4 mg or placebo once weekly
Oral Semaglutide for Type 2 diabetes was approved by the FDA in 2019 with an up to 14mg dose
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The Weight Regain Evidence Most patients regain 5070% of lost weight within 12 months of stopping without a structured maintenance plan Hunger and cravings typically return to pre-treatment levels within 24 weeks of stopping Metabolic improvements (blood sugar, blood pressure, lipids) also partially reverse after stopping Patients who built strong protein and exercise habits during treatment maintain significantly more of their weight loss 6
Now the concern shifts from acute overdose risk to long-term safety and sustainability
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