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AOD-9604 does not affect IGF-1 levels, insulin sensitivity, or glucose tolerance
L.FriedmanJ
The example of phase 1 and phase 2 metabolism of phenytoin is shown in Figure 61
Without IGFBP binding, IGF-1 LR3 remains in free, receptor-accessible form for 5672 hours substantially longer than native IGF-1's 1020-minute half-life when not IGFBP-bound
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