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Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion
However, in ME/CFS and dysautonomia, this vital switching mechanism becomes severely impaired, leaving patients unable to generate the rapid ATP required for basic daily activities
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