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Moreover, elevated systemic concentrations of TMAO enhanced thrombosis potential in vivo in animal models (4), and in recent clinical intervention studies, elevation in plasma TMAO induced with dietary choline supplementation altered platelet hyperresponsiveness in subjects (omnivores and vegans/vegetarians alike), as monitored by platelet aggregometry (17)

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Diet supplementation with mixed choline sources, with low free choline but high glycerophosphocholine, increases the frequency of cytotoxic CD8 + T cells expressing CD27, CD71, and CD127, as well as total B cells (CD45RA + ) and dendritic cells (OX6 + OX62 + ) ( 2.2.3 NK cells Natural killer (NK) cells are innate lymphocytes that contribute to the immune response against malignancies and viral infections