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Acknowledgments We thank Frontiers in Molecular Biosciences for their invitation to publish our manuscript

CagriSema combines two proven mechanisms (amylin + GLP-1) in a fixed-dose injection, achieving 20.4% weight loss in Phase 3, with an NDA already filed and the advantage of building on the well-characterized semaglutide platform

The liposomal delivery system is the real differentiator here

Notably, phosphorylated SMAD2/3 (pSMAD2/3) is not detected in LECs during the first 24 hours after lens injury in vivo , and this readout of canonical TGF signaling is not robustly detected in remnant LECs until 72 hours PCS, likely due to the need of injured LECs to upregulate the genes needed for TGF activation (199)

For Ozempic users not ready to explore peptides, creatine supplementation combined with resistance training offers an accessible starting point for muscle preservation