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net revenues from just two compounds last year: $22 billion from Novos semaglutide same drug, three brand names: Ozempic, Rybelsus, and Wegovy, and $27 billion from Lillys tirzepatide, a single drug marketed under the brand names of Mounjaro and Zepbound

A slower, more distributed increase, possibly over a longer period (e.g., adjusting the amount monthly instead of weekly), could allow the body more time to adapt

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Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, et al: Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons