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Independent of weight loss, semaglutide (Ozempic) improves knee arthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial @Cell_Metabolism cell.com/cell-metabolis Weight loss only accounted for 33% of the reduction of major adverse cardiovascular events (MACE) in the large trial of semaglutide vs placebo thelancet.com/journals/lance Good, concise summary @grok Glp-1s for addiction medicine is another benefit
Most of my patients have minimal or no nausea
The risk can be lowered by reducing the dose of sulfonylurea like gliclazide or insulin, when initiating treatment with GLP-1 analogue
The first three are non-negotiable
You dont have to rely on willpower alone
