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The clinical research that established GHK-Cu's effects on collagen synthesis, wound healing and skin remodelling was largely conducted using creams and serums applied to the skin

The compound includes a tyrosine (Tyr) residue added to the N-terminus of the native HGH fragment 176-191, a structural modification that distinguishes AOD-9604 from unmodified HGH Fragment 176-191 and contributes to its stability profile in laboratory conditions

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Nature 448:427434 Podolsky DK (2002) Inflammatory bowel disease

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