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A recent randomized placebo-controlled trial published by Scirica et al, known as SAVOR-TIMI 53, found no significant difference in ischemic events but did observe higher hospitalizations for heart failure with saxagliptin

Treatments can include Cognitive Behavioral Therapy to help rewire existing thought patterns and nutritional therapy by a registered dietitian

High protein intake, proper hydration, smart supplementation (such as creatine, EAAs, and omega-3s), and consistent resistance training all play a key role in protecting lean tissue

Peptide medications, like most GLP-1 drugs, are especially challenging to deliver through the skins barrier because of their large molecular size

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