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One study reported that GLP-1 is negatively correlated with body mass index (BMI) and that it appears to increase dentate gyrus neurogenesis based on immunostaining images (Coplan et al., 2014)

Bioavailability, effectiveness for gut vs systemic conditions, and choosing the right route

2,13,15 The occurrence of GI AEs associated with GLP-1 RAs is well established, but direct comparisons of incidence and severity across individual agents are less consistently reported

Hypothalamic Pathway The hypothalamus regulates GHRH and somatostatin secretion, which determine the timing of GH pulses

doi: 10.1073/pnas.1403438111 97 TanLGurbaniDWeisbergELHunterJCLiLJonesDSet al