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Finally, we show that GSH synthesis in the liver suppresses the activity of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2)

This isn't necessarily dangerousGHK-Cu has an excellent safety profilebut it's a less targeted approach for a cosmetic goal

At the same time, it preserved the homeostasis of CD8+ splenocytes, maintaining their cytotoxic function without provoking an excessive inflammatory response [50], suggesting Epitalons role in recalibrating, rather than overactivating, immune function

Kano Y, Tohyama M, Aihara M, et al

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