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The prolonged activity of incretin hormones produces two key effects that help lower blood glucose levels: Increased insulin secretion from the pancreatic beta cells in response to meals Reduced glucagon release from pancreatic alpha cells, which limits unnecessary glucose production by the liver Because these effects are glucose-dependent meaning they are most pronounced when blood sugar is already elevated DPP-4 inhibitors carry a relatively low risk of hypoglycaemia when used alone or with metformin
The most common experience during week 1 includes: Mild-to-moderate nausea, especially after eating Reduced appetite and an earlier feeling of fullness Possible fatigue or low energy as calorie intake drops Mild headache, often linked to reduced food and fluid intake The starting dose for Ozempic is 0.25 mg weekly
What can trigger pancreatitis
Semaglutide was approved a few years later, in 2021
Use a new sterile syringe for each injection
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