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The rapid production of ROS in activated neutrophils, which requires increased pentose cycling, and thus increased G6PD activity, acts to promote NETosis via oxidative inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (13)

Available online at: (Accessed July 20, 2025)

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The more intense the activity is (think a 100-meter sprint or a 5-rep max set of squats), the more quickly you burn through the available ATP, which leads to fatigue