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Detrimental accumulation of specifically nitrated proteins is observed in aging 42,43 and a variety of disorders including Alzheimers and Parkinsons diseases 44,45,46

4.3 Reproduction To ensure a required gene expression pattern to support embryonic development, the maternal (oocyte) and paternal (sperm) epigenome are remodeled to reach totipotency, driving cellular differentiation toward all cell types (Ross and Sampaio, 2018), including embryonic and extraembryonic ( i.e ., placenta) cell types

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