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Despite the novelty of this study, several limitations exist

In these studies, more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received a placebo

The sequence Gly-His-Lys binds copper(II) ions through a coordination complex involving the histidine imidazole nitrogen, the terminal amino group, and the deprotonated amide nitrogen of the Gly-His peptide bond

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18, 19, 65, 66 In addition, this offers a potential explanation for temporary behavioral improvements in some patients following vancomycin or metronidazole treatment, which eradicates these bacteria 18, 19, 66 and profoundly reduces stool PPA