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Additionally, CCR6 is also expressed on gamma delta () T cells, which have been implicated in the pathogenesis of several chronic inflammatory diseases (125), and in IL-17A + innate-like lymphocytes in the mouse LN subcapsular sinus, involved in innate responses against lymph-borne pathogens (127)

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Why target senescent cells

ERK1/2 activation upregulates collagen gene expression and promotes cell proliferation critical for fibroblast proliferation, while p38 MAPK inhibition reduces inflammatory response