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C.RoufogalisB
2023 May 4;18(5):e0285197
Mechanism of Action 5-Amino-1MQ inhibits NNMT, the enzyme that transfers a methyl group from SAM onto nicotinamide
This process reduces caloric intake
A decrease in GSH can be due to three reasons: (I) a decrease in ATP prevents the enzyme 5-oxoprolinasa (ATP-dependent) from converting PyroGlu into Glu, causing PyroGlu to accumulate, and thus, the gamma-glutamyl cycle becomes blocked
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