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Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025
Further studies showed the microspheres could reduce weight gain in mice placed on an obesogenic weight gain-promoting diet
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Several such patents have been filed and granted in the last 5 years (Table 5)
Secondly, metformin activates adenosine monophosphate (AMP)-activated kinase (AMPK), the master regulator of energy utilisation by cells
