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Moreover, efforts are currently being made to develop GPX4-selective covalent inhibitors with minimal toxicity and better tolerance profiles [106, 107]
With a few drugs, such as phenylbutazone, ethanol, deracoxib, and phenytoin, or if very large doses of a drug are given, the drug concentrations achieved are much greater than K m and the rate equation is as follows: The enzymes are saturated by the high free drug concentrations, and the rate of metabolism remains constant over time
Funding This study was supported by Centros de Investigacin Biomdica en Red (CIBER) of Instituto de Salud Carlos III (ISCIII) (CB06/03/0018) and research grants from the ISCIII (PI18/01160), and co-financed by the European Regional Development Fund (ERDF)
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